RESUMO
PURPOSE: The purpose of this study was to determine the prevalence, severity and quality of life for nurses with hand dermatitis who want to take advantage of measures to manage their hand dermatitis. METHODS: Participants in this research were 422 nurses with clinical experience of more than 12 months. Data were collected using a diagnostic tool for hand dermatitis, subjective severity and objective severity. The skin related quality of life was measured using the Korean version of Skindex-29. Data were analyzed using χ2 tests, t-test, and ANOVAs with SPSS 20.0. RESULTS: The prevalence of hand dermatitis among the respondents was 56.9% (240/422). Nurses with hand dermatitis had significantly lower quality of life than nurses with no hand dermatitis. The more severe the hand dermatitis, the lower the quality of life was. CONCLUSION: The finding in this study indicate that there is a need to improve the health of nurses by lowering the prevalence of hand dermatitis, alleviating the severity of hand dermatitis and improving the quality of life.
Assuntos
Dermatite , Mãos , Prevalência , Qualidade de Vida , Pele , Inquéritos e QuestionáriosRESUMO
We analyzed the occurrence of enteric viruses and bacteria at 22 places of drinkable groundwater (civil defense emergency water-supply facility), 8 places of the groundwater used for drinking water in group food services, and 10 places of spring-water. When the 40 concentrated samples were analyzed using nested RT-PCR and real-time RT PCR methods, norovirus and other enteric viruses were not detected in all samples tested. The detection percentages for total coliforms, Escherichia coli, Yersinia enterocolitica of fecal indicator were 57.5%, 22.5% and 7.5%, respectively. Colipages were not detected. These results suggest that high levels of fecal indicator bacteria in groundwater and spring-water are not directly related to occurrence of enteric viruses.
Assuntos
Bactérias , Água Potável , Emergências , Escherichia coli , Serviços de Alimentação , Água Subterrânea , Norovirus , Reação em Cadeia da Polimerase , Yersinia enterocoliticaRESUMO
The massive reorganization of microtubule network involves in transcriptional regulation of several genes by controlling transcriptional factor, nuclear factor-kappa B (NF-kappaB) activity. The exact molecular mechanism by which microtubule rearrangement leads to NF-kappaB activation largely remains to be identified. However microtubule disrupting agents may possibly act in synergy or antagonism against apoptotic cell death in response to conventional chemotherapy targeting DNA damage such as adriamycin or comptothecin in cancer cells. Interestingly pretreatment of microtubule disrupting agents (colchicine, vinblastine and nocodazole) was observed to lead to paradoxical suppression of DNA damage-induced NF-kappaB binding activity, even though these could enhance NF-kappaB signaling in the absence of other stimuli. Moreover this suppressed NF-kappaB binding activity subsequently resulted in synergic apoptotic response, as evident by the combination with Adr and low doses of microtubule disrupting agents was able to potentiate the cytotoxic action through caspase-dependent pathway. Taken together, these results suggested that inhibition of microtubule network chemosensitizes the cancer cells to die by apoptosis through suppressing NF-kappaB DNA binding activity. Therefore, our study provided a possible anti-cancer mechanism of microtubule disrupting agent to overcome resistance against to chemotherapy such as DNA damaging agent.
Assuntos
Animais , Humanos , Camundongos , Antibióticos Antineoplásicos/uso terapêutico , Apoptose , Caspases/metabolismo , Linhagem Celular , Colchicina/farmacologia , DNA/metabolismo , Dano ao DNA , Doxorrubicina/uso terapêutico , Microtúbulos/química , NF-kappa B/antagonistas & inibidores , Neoplasias/tratamento farmacológico , Nocodazol/farmacologia , Ligação Proteica , Transdução de Sinais , Moduladores de Tubulina/farmacologia , Vimblastina/farmacologiaRESUMO
PURPOSE: We did this study to find out the current teaching status of the medical humanities and social sciences curriculum in Korean medical schools. Further, we discuss the tasks at hand to improve the curriculum in medical education. METHODS: The curricula of 41 medical schools and the syllabi of 10 schools were examined. We analyzed the tables of course organization and contents of integrated medical humanities. After analysis of the contents, they were grouped into 6 categories of medical humanities and social sciences domain. RESULTS: Our results are as follow: 1) there are 3 types of medical humanities and social sciences subject forms: inter-disciplinary (integrated, for example, PDS), multi-disciplinary (separated subject form), and mixed (integrated+separated); 2) most schools offer medical humanities and social sciences in a required class; 3) medical humanities and social sciences are taught through all school years and all 8 graduate medical schools offer a medical humanities and social sciences course from year 1; and 4) the average academic credits for medical humanities are 10 or 11. With respect to the curriculum content, there is some commonality in 10 schools: disease prevention, health improvement, medical ethics, medical regulation, professionalism, and community medicine. Differences were seen in content selection and organization. CONCLUSION: After brief reviews of the medical humanities and social science curriculums, we discovered that all Korean medical schools meet the need of medical humanities and social sciences education. However, curriculum implementation differed in various ways. We suggest the following tasks: 1) clarification of educational goals in order to develop a core curriculum of medical humanities and social sciences in Korea; 2) sharing experiences of developing a well-designed curriculum with other medical schools for effective teaching of this subject area.